Table 1. Sample details and treatments.
Sample | Hydration | Classification | Riboflavin/UVA treatment |
Hypo-osmolar riboflavin/UVA cross-linking: Keratoconus | |||
K1 | 2.2 | Keratoconus; unswollen | Hypo-osmolar |
K2 | 3.8 | Keratoconus; swollen | Hypo-osmolar |
Hypo-osmolar riboflavin/UVA cross-linking: Normal | |||
N1 | 2.3 | Normal; unswollen | Hypo-osmolar |
N2 | 2.4 | Normal; unswollen | Hypo-osmolar |
N3 | 2.1 | Normal; unswollen | Hypo-osmolar |
N4 | 2.5 | Normal; unswollen | Hypo-osmolar |
N5 | 6.6 | Normal; swollen | Hypo-osmolar |
N6 | 6.6 | Normal; swollen | Hypo-osmolar |
Iso-osmolar riboflavin/UVA cross-linking: Normal | |||
N7 | 2.0 | Normal; unswollen | Iso-osmolar |
N8 | 1.9 | Normal; unswollen | Iso-osmolar |
N9 | 2.5 | Normal; unswollen | Iso-osmolar |
N10 | 5.7* | Normal left; swollen | Iso-osmolar |
N11 | 5.7 | Normal right; swollen | None (control for N10) |
N12 | 5.3* | Normal left; swollen | Iso-osmolar |
N13 | 5.3 | Normal right; swollen | None (control for N12) |
N14 | 5.2* | Normal left; swollen | Iso-osmolar |
N15 | 5.2 | Normal right; swollen | None (control for N14) |
Details of pre-treatment tissue hydration (recorded at the time of data collection), classification and UVA cross-linking treatment (hypo-osmolar/iso-osmolar riboflavin solution) are shown for each sample. Each cornea has been classified as being either ‘unswollen’ (at or below a physiological hydration of H = 3.2) or ‘swollen’ (above physiological hydration).
*The pre-treatment hydration of samples N10, N12 and N14 was assumed to be the same as that of their untreated pair (N11, N13 and N15 respectively).