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. 2011 Aug 5;6(8):e22742. doi: 10.1371/journal.pone.0022742

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Head et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A, time taken for force to fall to 50% of original force. Creatine incubation resulted in a significant increase in this parameter. B, pattern of force decline during the fatigue run, showing the effect of creatine treatment in improving the resistance of muscles to fatigue. It is evident that creatine incubation is associated with an increase in the time taken for force to fall to 50%, as well as a reduction in the total force decline over the whole fatigue run. Statistically significant differences are indicated by “*” (P<0.05).