Table 1.
Long QT subtypes classified by final common pathways
| Current | Long QT subtype |
Genes | Protein | Function |
|---|---|---|---|---|
| IKs | LQT1 | KCNQ1 | Kv7.1 | α-Subunit IKs |
| LQT5 | KCNE1 | minK | β-Subunit IKs | |
| LQT11 | AKAP9 | Yotiao | Regulatory adaptor IKs |
|
| IKr | LQT2 | KCNH2 | Kv11.1 | α-Subunit IKr |
| LQT6 | KCNE2 | MiRP1 | β-Subunit IKr | |
| INa | LQT3 | SCN5A | Nav1.5 | α-Subunit INa |
| LQT4 | ANK2 | Ankyrin B | Adaptor INaK INa–Ca, INa |
|
| LQT9 | CAV3 | M-Caveolin | Adaptor INa | |
| LQT10 | SCN4B | Navb4 | β-Subunit INa | |
| LQT12 | SNTA1 | a-1-Syntrophin | Scaffolding protein INa |
|
| Ik1 | LQT7 | KCNJ2 | Kir2.1 | α-Subunit IK1 |
| ICaL | LQT8 | CACNA1C | Cav1.2 | α-Subunit ICaL |