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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Cancer Prev Res (Phila). 2011 May 5;4(8):1158–1171. doi: 10.1158/1940-6207.CAPR-10-0006

Table IV.

Microparticle/microemulsion formulations of curcumin.

Formulation Method Particle
Size		 Encapsulation
Efficiency (%)		 Advantages Refs.
Curcumin macrocapsules prepared with gelatin. Coacervation Method 80–90 µm 75.5

  • Improved stability coupled with controlled release.

 90
PLGA microparticles of curcumin for parenteral administration. Emulsion Solvent Evaporation 22±9 µm 75

  • Sustained plasma curcumin levels for upto a month after a single s/c injection.

  • Enhanced efficacy as compared to powder curcumin.

 91
Curcumin microemulsion (o/w) formulated into a hydrogel matrix for topical application. Surfactant mediated Microemulsification 45–50 nm N. R.

  • Porous polymeric network providing controlled release.

  • Increases skin hydration.

 88
Microemulsified curcumin loaded SLNs for topical appication. Microemulsification 450 nm (PDI 0.4) 70

  • Increased photostability.

 89

N. R.: Not Reported