Table II.

Size Analysis of Protein Samples by HP-SEC Quantified from UV Detection at 280 nm

	Monomer [%]	Dimer [%]	HMW [%]	Fragments [%]	Recovery [%]	Soluble aggregates + non-recovered fraction [%]
Etanercept, NS	93.0	1.3	0.0	5.6	100.0	7.0
Etanerecept, 10 min 65°C	88.9	3.5	2.0	5.6	96.6	14.1
Etanerecept, 10 min 70°C	81.3	6.0	7.4	5.3	95.8	22.1
Adalimumab, NS	99.3	0.4	0.0	0.3	100.0	0.7
Adalimumab, 10 min 60°C	96.8	1.0	1.8	0.3	101.6	1.7
Adalimumab, 10 min 65°C	58.3	1.8	39.5	0.3	69.6	59.4
IgG, NS	99.1	0.0	0.0	0.9	100.0	0.9
IgG, 10 min 75°C	95.4	3.0	0.0	1.6	94.8	9.6
IgG, 10 min 80°C	45.0	8.0	44.3	2.7	87.2	60.8
Rituximab, NS	99.4	0.6	0.0	0.0	100.0	0.6
Rituximab, 10 min 60°C	98.9	0.7	0.4	0.0	100.5	0.6
Rituximab, 10 min 65°C	97.3	1.0	1.7	0.0	98.5	4.2