FIG. 2.

Transient receptor potential (TRP) protein family. (a) The TRP proteins constitute a superfamily of which there are seven subfamilies. The TRPC (canonical) subfamily most closely resembles the TRP protein (red) originally identified in Drosophila melanogaster. Adapted from Minke (74). (b) Functional cation channels are believed to be formed by oligomerization of TRP proteins into hetero- or homotetramers. Reprinted with permission from (61) and (83). (To see this illustration in color the reader is referred to the web version of this article at www.liebertonline.com/ars).