Biochemical pathways and inter-relationships between different oxidative species. Superoxide (), GSH, GSSG, glutathione peroxidase (GSH-Px), glutathione reductase (GSH-Red.), total nitric oxide synthase (tNOS), nitric oxide (NO), peroxynitrite (ONOO−), hydrogen peroxide (H2O2), hydroxide anion (−OH), hydroxyl radical (OH•), polyunsaturated fatty acid (PUFA), oxidized nicotinamide adenine dinucleotide phosphate (NADP+), adenosine monophosphate (AMP), and adenosine 5′-diphosphoribose (ADPR). Modified from Naziroğlu (80). (To see this illustration in color the reader is referred to the web version of this article at www.liebertonline.com/ars).