Table 2.
Role of Superoxide Dismutases in Atherosclerosis
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Fold change of lesion |
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|---|---|---|---|---|---|---|---|
| SODs | Gene altered | Genetic background | Diet and intervention | Increase | No change | Decrease | Reference |
| SOD1 (Cu/ZnSOD) | |||||||
| 1 | SOD1 Tg | B6 | High fat (add irradiation) | 2 | 219 | ||
| 2 | SOD1 Tg | B6 | High fat | 2.2 | 220 | ||
| 3 | SOD1 Tg | ApoE −/−/B6 | high fat | NS | 245 | ||
| SOD1 + catalase Tg | ApoE −/−/B6 | High fat | 4 | ||||
| SOD2 (MnSOD) | |||||||
| 4 | SOD2+/− | ApoE−/−/B6 | High fat | 2.5 | 12 | ||
| SOD3 (ecSOD) | |||||||
| 5 | SOD3−/− | ApoE−/−/B6 | Normal chow | NS (after 3M) | 1.7 (after 1M) | 204 | |
| High fat | NS | ||||||