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The multiple pathways of mitochondrial regulation by p53. These are: (1) assembly of the oxidative phosphorylation complexes; (2) mitochondrial deoxyribonucleic acid (mtDNA) repair, replication, and transcription through DNA polymerase γ, p53-inducible ribonucleotide reductase 2 (p53R2), and TF1M; and (3) autophagy for normal mitochondrial homeostasis. (To see this illustration in color the reader is referred to the web version of this article at www.liebertonline.com/ars).
