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. Author manuscript; available in PMC: 2011 Aug 6.
Published in final edited form as: Curr Drug Targets. 2009 Jul;10(7):581–589. doi: 10.2174/138945009788680392

Fig. (1). The mammalian and Drosophila Rb family proteins.

Fig. (1)

The Rb family of proteins in mammals consists of Rb, p107 and p130, and in Drosophila contains RBF and RBF2. The pocket domain, which is shaded in grey, is conserved and is responsible for most protein-protein interactions. A cyclin/cdk interaction motif (shaded in black) is conserved in the spacer region of p107 and p130 but absent in Rb protein. The activity of Rb proteins is controlled by phosphorylation at numerous phosphorylation sites (indicated for Rb and RBF by *). The phosphorylation sites in other Rb family members have not been precisely mapped.