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. Author manuscript; available in PMC: 2012 Aug 5.
Published in final edited form as: Circ Res. 2011 Aug 5;109(4):453–462. doi: 10.1161/CIRCRESAHA.110.239749

Figure 1. Compiled schema of calpain-related signaling during the development of cardiac hypertrophy.

Figure 1

?=possible intermediates/connections not yet determined; FAK, focal adhesion kinase; HSP90, heat shock protein 90; GSK3β, glycogen synthase kinase 3 beta; GATA4, GATA binding protein 4; p65/p50, NF-κB heterodimer; NOX, NADPH oxidase; Ang II, angiotensin II. *indicates mechanisms identified in non-cardiomyocyte systems.