Table 3.
The marker genes of three different grades of ACM.
| Gene symbol | II-astro score | III-astro score | IV-astro score | Normal-score | II-mean (log base 2) | III-mean (log base 2) | IV-mean (log base 2) | Normal mean (log base 2) |
|---|---|---|---|---|---|---|---|---|
| EPHB1 | 15.4462 | 0 | 0 | 0 | 6.869894 | 2.55495 | 2.65409 | 2.72811 |
| LOC732229 | 13.8658 | 0 | 0 | 0 | 5.460512 | 2.59371 | 2.77408 | 2.26366 |
| C12orf39 | 8.5766 | 0 | 0 | 0 | 5.361751 | 2.238085 | 2.58682 | 2.48695 |
| MARVELD3 | 7.8886 | 0 | 0 | 0 | 6.800398 | 2.37729 | 2.86839 | 2.39552 |
| LOC283677 | 4.4758 | 0 | 0 | 0 | 3.883122 | 2.826663 | 2.71392 | 2.8898 |
| C20orf42 | 3.5577 | 0 | 0 | 0 | 7.627308 | 2.859789 | 2.4558 | 2.52664 |
| SPTLC3 | 3.2679 | 0 | 0 | 0 | 4.01698 | 2.255256 | 2.30132 | 2.59188 |
| KCNQ1OT1 | 2.9128 | 0 | 0 | 0 | 4.103731 | 2.338234 | 2.2464 | 2.26363 |
| FLJ21062 | 2.1167 | 0 | 0 | 0 | 4.753168 | 2.238085 | 2.48495 | 2.26875 |
| ATP13A5 | 1.9707 | 0 | 0 | 0 | 3.214755 | 2.238085 | 2.2464 | 2.43345 |
| PDXDC1 | 1.3847 | 0 | 0 | 0 | 3.134729 | 2.25661 | 2.26636 | 2.26363 |
| CNNM2 | 0.8081 | 0 | 0 | 0 | 3.148803 | 2.27347 | 2.6133 | 2.54342 |
|
| ||||||||
| ZBTB39 | 0 | 15.0318 | 0 | 0 | 4.173501 | 6.19055 | 4.6856 | 4.68794 |
| C6orf89 | 0 | 11.2219 | 0 | 0 | 2.621672 | 4.699428 | 2.91788 | 2.30613 |
| LOC116236 | 0 | 11.0126 | 0 | 0 | 2.254329 | 4.397317 | 2.72612 | 2.44326 |
| FKHL18 | 0 | 10.2107 | 0 | 0 | 2.258635 | 3.994112 | 2.2464 | 2.6121 |
| CTRL | 0 | 10.0666 | 0 | 0 | 2.526428 | 3.937424 | 2.31851 | 2.58541 |
| TIRAP | 0 | 9.5523 | 0 | 0 | 2.324936 | 4.216794 | 2.2464 | 2.75954 |
| NEUROG1 | 0 | 2.5236 | 0 | 0 | 2.258056 | 3.768388 | 2.64751 | 2.27475 |
| TMEM44 | 0 | 0.4603 | 0 | 0 | 2.315798 | 3.374982 | 2.45605 | 2.51802 |
| RPUSD1 | 0 | −0.647 | 0 | 0 | 4.034009 | 2.703442 | 3.84208 | 4.14466 |
| DHRS7 | 0 | −2.0711 | 0 | 0 | 3.425335 | 2.573317 | 3.60534 | 4.03533 |
| AKAP7 | 0 | −2.6126 | 0 | 0 | 4.723465 | 2.652648 | 5.11056 | 3.7332 |
| PDE3B | 0 | −4.2169 | 0 | 0 | 5.989233 | 4.535432 | 6.10718 | 6.31594 |
|
| ||||||||
| C20orf160 | 0 | 0 | 14.9825 | 0 | 2.523126 | 2.790445 | 4.41487 | 2.27477 |
| PKMYT1 | 0 | 0 | 11.89 | 0 | 2.644079 | 2.486864 | 3.84824 | 2.26751 |
| TRPV2 | 0 | 0 | 10.5089 | 0 | 2.397686 | 2.732524 | 4.5048 | 3.31894 |
| LEFTY2 | 0 | 0 | 5.3507 | 0 | 2.231583 | 2.258491 | 5.56688 | 2.28191 |
| C20orf77 | 0 | 0 | 5.1848 | 0 | 2.333998 | 2.404051 | 3.48131 | 2.3379 |
| MOBKL2C | 0 | 0 | 3.8936 | 0 | 2.517987 | 2.58549 | 3.86723 | 2.45653 |
| STAC | 0 | 0 | 2.9965 | 0 | 2.275399 | 2.238151 | 6.32448 | 2.78522 |
| GGA3 | 0 | 0 | 2.8351 | 0 | 2.295872 | 2.433914 | 3.46887 | 2.26651 |
| VAV1 | 0 | 0 | 2.1584 | 0 | 2.396392 | 2.515654 | 4.53627 | 2.34353 |
| TXNRD2 | 0 | 0 | 1.3886 | 0 | 2.582906 | 2.358745 | 3.38602 | 2.41848 |
| SP100 | 0 | 0 | 0.9134 | 0 | 2.385938 | 2.339246 | 3.58699 | 2.37374 |
| LCP2 | 0 | 0 | 0.7656 | 0 | 2.268675 | 2.292975 | 3.62601 | 2.88405 |
| RHEB | 0 | 0 | 0.6002 | 0 | 2.254732 | 2.244571 | 3.16583 | 2.31595 |
The first column lists the marker genes for different ACM WHO grades; the scores from 2th to 5th columns suggest the estimates of the class probabilities by PAM [4], which are similar to that used in linear discriminant analysis (LDA); the means from 6th to 9th columns represent the average values of log (base 2) gene expression. Bold indicates a marker gene of one WHO grade ACM relative to other WHO grades which are overexpressional; italic indicates those that are underexpressional.