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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Curr Opin Struct Biol. 2011 Feb 1;21(2):257–264. doi: 10.1016/j.sbi.2011.01.003

Figure 4. SCF-I2 allosterically inhibits the Cdc4 WD40 β-propeller from binding to a phosphodegron.

Figure 4

Superposition of the CRL1 SR Cdc4 WD40 β-propeller from structures of complexes with a phosphodegron peptide (Cdc4 – purple; phosphodegron lime) or with SCF-I2 (Cdc4 – pink; SCF-I2 – yellow). SCF-I2 (yellow) intercalates between two blades of the propeller (pink) that leads to a continuum of structural distortions over 25 Å, ultimately preventing interaction with a phosphodegron.