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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Trends Immunol. 2011 Jul 4;32(8):373–379. doi: 10.1016/j.it.2011.05.004

Figure 2. Obesity is a key facilitator of NLRP3 inflammasome induction in metabolic disease.

Figure 2

Obesity often supplies the initial signals required to prime the NLRP3 inflammasome that can include modified LDL and free fatty acids. Many of the metabolic danger signals subsequently sensed by the NLRP3 inflammasome are also a direct/indirect result of obesity. Once the inflammasome has been engaged by a specific danger signal the resulting pro-inflammatory induced state often leads to progression of a particular metabolic disease.