. Author manuscript; available in PMC: 2012 Aug 1.

Published in final edited form as: Trends Immunol. 2011 Jul 4;32(8):373–379. doi: 10.1016/j.it.2011.05.004

Table 1.

Metabolic dangers signals triggering formation of the NLRP3 inflammasome

Metabolic danger signal	Disease state	References
Amyloid beta	Alzheimer’s disease	[4]
Calcium pyrophosphate dehydrate (CPPD) crystals	Pseudogout	[3]
Ceramides	Obesity	[42]
Cholesterol crystals	Atherosclerosis	[19]
Islet amyloid peptide (IAPP)	T2D progression	[23]
Monosodium urate (MSU) crystals	Gout	[3]
Palmitate	Early T2D	[46]