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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: J Med Primatol. 2011 Jul 1;40(4):206–213. doi: 10.1111/j.1600-0684.2011.00484.x

Table 1.

Changes in mDCs and chemokines at virus set-point in SIV-infected rhesus macaques with different disease outcomes1

Parameter Stable SIV infection2 Progressive SIV infection3
Number of mDCs in blood Increased to ~200% of pre-infection levels4 Decreased to 60% of pre-infection levels
Activation of mDCs in blood Minor increase in CCR7; CD80/86 elevated Major increase in CCR7; CD80/86 elevated
Proportion of mDCs in lymph node Similar to naïve Similar to naïve
Activation of mDCs in lymph node CCR7, CD40, CD86, MHC class II low CCR7, CD40, CD86, MHC class II normal
Expression of CCL19 mRNA in lymph node Similar to naïve 8-fold higher than naïve
Apoptosis of mDCs in lymph node Similar to naïve 3-fold higher than naïve
1

Data adapted from [53]

2

Healthy at elective sacrifice at a mean of 60 weeks post infection (range 56 to 63 weeks)

3

Sacrificed due to AIDS-defining illness at a mean of 32 weeks post infection (range 11 to 43 weeks)

4

Blood mDCs in stable infection had initial decline at 2 weeks post infection