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Hepatocyte apoptosis in obese LDLR−/− fed dietary cholesterol. A: TUNEL staining of liver sections. Chow diet, open bars (n = 8); DD, hatched bars (n = 10); DDC, solid bars (n = 10). *P < 0.05 versus chow; **P < 0.01 versus DD; ***P < 0.001 versus chow. B: The number of apoptotic cells correlates with hepatic triglyceride content and (C) with ALT levels, a marker of hepatocellular damage. DD, filled circles; DDC, filled diamonds.
