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Levels of circulating leptin at weeks 0, 4, and 8 in control (Con) and AICAR-treated animals (A). Assessment of phosphorylation and content of AMPK and SOCS3 in the hypothalami of rats at 4 and 8 weeks (B). Control and AICAR-treated animals are denoted as ‘C’ and ‘A’, respectively. Two-way ANOVA with Bonferroni post hoc tests. *P < 0.05 versus all other conditions; #P < 0.05 versus all other conditions. Data are expressed as mean ± SEM.
