Table 1.

Causes of allograft injury^a

Immunologic (Antigen Dependent)	Nonimmunologic (Antigen Independent)
Cellular immunity	Organ viability
direct versus indirect allorecognition	donor senescence
donor–host mismatch	donor age
subclinical inflammation	prolonged cold ischemic time
co-stimulatory signaling	delayed graft function/acute tubular necrosis
inadequacy of immunosuppression	living versus deceased
Humoral immunity	reduced renal mass
antibody-mediated rejection	donor brain injury
previous sensitization	Treatment
Infection	drug toxicity
CMV	Recipient factors
BK polyomavirus	lipid disorders
	diabetes
	recurrent disease
	compliance
	hypertension
	obstruction

^aCMV, cytomegalovirus.