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. 2011 Apr 12;39(14):6201–6212. doi: 10.1093/nar/gkr165

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Haplotypes of COMT and corresponding expression levels. (a) Organization of SNPs for the three haplotypes along COMT gene. Percent frequency of each haplotype from a cohort of 202 healthy Caucasian females is indicated on the right (6). The LPS designed mutant used for later experiments is also included for comparison. (b) In vitro translation in rabbit reticulocyte lysates. Both LPS and HPS share the same expression levels, while APS exhibits higher expression levels. To test whether this is due to the rs4633 SNP near the start codon, we mutated the LPS variant from ¹⁶⁶C to ¹⁶⁶T. The resultant LPS-T¹⁶⁶ mutant displays expression levels on par with APS.