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. 2011 Mar 31;39(14):5935–5944. doi: 10.1093/nar/gkr187

Figure 4.

Figure 4.

Mild and severe HDR disruption lead to distinct chromosome segregation defects. (A) Shown is the percentage of early anaphases with PICH linkages in 293A7, g4Rad51KR, g4Rad51KA cells after L-treatment. (B) Mild and severe HDR-deficiency causes PICH–UFBs. Shown is the percentage of late anaphases with PICH–UFBs for the cells shown in A. (C) As measured by DAPI, severe HDR-deficiency causes chromosome separation defects to a greater degree than a mild HDR-deficiency. Shown is the percentage of late anaphases with DAPI-bridges for the cells shown in A. (D) Shown is the percentage of total anaphase abnormalities (e.g. DAPI-bridges, laggards or multipolar anaphases) for the cells shown in A. n > 100 anaphases analyzed for each cell line. Asterisk denotes a difference in frequency compared to untreated condition (P < 0.0003). Open diamond denotes a difference of g4Rad51KA compared to g4Rad51KR (P < 0.01).

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