Figure 6.

Model for consequences of mild versus severe HDR disruption on anaphase and cell viability. Both severe and mild HDR deficiencies lead to incomplete chromosome separation, as measured by PICH–UFBs (red) and DAPI bridges (blue). Cells with a mild HDR deficiency retain bipolar chromosome separation and viability, but are incapable of limiting anaphase abnormalities and hence are prone to CIN. In contrast, severe HDR deficiency additionally causes multipolar anaphases resulting mostly from binucleated cells and eventual cell death.