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. 2011 Apr 21;39(14):6002–6015. doi: 10.1093/nar/gkr193

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — ZIM17 deletion confers nuclear genome instability. (A) The zim17Δ leads to hyperrecombination in plasmidic recombination systems (L: direct repeats, LY: direct repeats disrupted by a transcribed sequence and SU: inverted repeats). (B) Schematic representation of the leu2-k::URA3-ADE2::leu2-k recombination system (top). Recombination between the direct leu2-k repeats results in the loss of URA3 and ADE2 markers and resistance against FOA (5-FOA^R). Recombination frequencies in WT (white) and zim17Δ (gray) of respiratory competent (rho⁺) and deficient (rho⁻) strains are indicated (bottom). Recombinants were selected by plating cells onto 5-FOA-containing SC medium. The relative fold increase in recombination with respect to the adequate WT strain is represented (right). (C) Schematic representation of the rDNA::URA3-ADE2::rDNA recombination system (top). Recombination frequencies are shown (bottom). Description as in (B).