Table 4.
KEGG pathway analysis for genes with validated non-synonymous mutations present in the HCC1954 and HCC1954BL genomes
| KEGG ID | KEGG annotation | Number of genes in the pathway | Gene Name | P-value |
|---|---|---|---|---|
| HCC1954 | ||||
| hsa05222 | Small cell lung cancer | 3 | ITGA6 TP53 TRAF2 | 0.0003 |
| hsa05410 | Hypertrophic cardiomyopathy | 2 | ITGA6 MYH7 | 0.0167 |
| hsa04210 | Apoptosis | 2 | TP53 TRAF2 | 0.0169 |
| hsa05414 | Dilated cardiomyopathy | 2 | ITGA6 MYH7 | 0.0191 |
| hsa04010 | MAPK signaling pathway | 3 | ARRB1 TP53 TRAF2 | 0.0237 |
| hsa00770 | Pantothenate and CoA biosynthesis | 1 | DPYD | 0.0325 |
| hsa04360 | Axon guidance | 2 | CFL2 SEMA3A | 0.0335 |
| hsa04614 | Renin-angiotensin system | 1 | LNPEP | 0.0372 |
| hsa05200 | Pathways in cancer | 3 | ITGA6 TP53 TRAF2 | 0.0375 |
| HCC1954BL | ||||
| hsa03440 | Homologous recombination | 1 | EME1 | 0.0234 |
| hsa00310 | Lysine degradation | 1 | SETD2 | 0.0382 |
| hsa04740 | Olfactory transduction | 2 | OR51E2 OR2D2 | 0.0421 |