Table 5.
Protein–protein interaction analysis for genes with non-synonymous mutations in other solid tumors
| References | Tumor type | Number of genes with non-synonymous mutations | Number of mutated genes with PPI information (%) | Average number of interactions for mutated genes (P-value) | Number of mutated genes with common partner (%) (P-value) | Number of common partners (P-value) |
|---|---|---|---|---|---|---|
| Pleasance et al. (8) | Lung | 90 | 50 (56) | 11.6 (0.2692) | 33 (66) (0.0001) | 42 (0.0870) |
| Pleasance et al. (7) | Melanoma | 188 | 100 (53) | 8.3 (0.8344) | 69 (69) (0.0001) | 103 (0.3130) |
| Ding et al. (4) | Breast basal | 29 | 17 (59) | 8.1 (0.2210) | 7 (41) (0.0001) | 7 (0.0132) |
| Shah et al. (9) | Breast lobular | 32 | 16 (50) | 32.5 (0.0034) | 7 (44) (0.0001) | 28 (0.0011) |
| Clark et al. (3) | GBM | 110 | 40 (36) | 12.9 (0.7269) | 18 (45) (0.0001) | 13 (0.1896) |
| Galante et al. (this study) | Breast HCC1954 | 45 | 25 (56) | 33.2 (0.0017) | 17 (68) (0.0001) | 64 (0.0001) |