TABLE 2.
Genes up- or down-regulated by 1.8-fold in human trabecular meshwork cells after over expression of miR-24 mimic
| Gene symbol | Fold change | Regulation | P-value | Database | Gene title |
|---|---|---|---|---|---|
| PTHLH | 3.0565975 | Down | 3.97E-04 | M,T,P | Parathyroid hormone-like hormone |
| CNDP2 | 2.4332333 | Down | 4.35E-05 | CNDP dipeptidase 2 | |
| IL8 | 2.2841344 | Down | 1.86E-04 | Interleukin 8 | |
| F2RL1 | 2.2676232 | Down | 4.22E-05 | T | Coagulation factor II (thrombin) receptor-like 1 |
| IL8 | 2.2576025 | Down | 4.99E-04 | P | Interleukin 8 |
| KIF3B | 2.2168906 | Down | 2.55E-05 | Kinesin family member 3B | |
| GALNT12 | 2.1888528 | Down | 0.0029251 | M | UDP-N-acetyl-alpha-D-galactosamine |
| RASSF2 | 2.15163 | Down | 2.69E-06 | Ras associationdomain family member 2 | |
| CXCL6 | 2.13901 | Down | 0.0017257 | Chemokine (C-X-C motif) ligand 6 | |
| SLC11A2 | 2.0708907 | Down | 1.35E-04 | Solute carrier family 11, member 2 | |
| C14orf2 | 2.0584471 | Down | 2.15E-05 | Chromosome 14 open reading frame 2 | |
| ANXA10 | 2.0433328 | Down | 3.64E-04 | Annexin A10 | |
| NPTX1 | 2.027866 | Down | 0.0187071 | Neuronal pentraxin I | |
| PDXK | 2.0209773 | Down | 1.01E-05 | T,P | Pyridoxal kinase |
| ENTPD6 | 2.0142882 | Down | 1.31E-04 | Ectonucleoside triphosphate diphosphohydrolase 6 | |
| KCNK3 | 1.9923251 | Down | 1.82E-04 | T,P | Potassium channel, subfamily K, member 3 |
| STC2 | 1.9881191 | Down | 1.43E-05 | T | Stanniocalcin 2 |
| HHLA3 | 1.9669507 | Down | 0.0013616 | HERV-H LTR-associating 3 | |
| CXCL1 | 1.9485825 | Down | 2.07E-04 | Chemokine (C-X-C motif) ligand 1 | |
| ACVR1B | 1.9390614 | Down | 2.84E-04 | M,T | Activin A receptor, type IB |
| MED16 | 1.9286143 | Down | 6.86E-04 | Mediator complex subunit 16 | |
| STC2 | 1.9134991 | Down | 5.14E-05 | Stanniocalcin 2 | |
| SYT1 | 1.9131047 | Up | 0.0040418 | Synaptotagmin I | |
| MICB | 1.8921673 | Down | 6.76E-05 | MHC class I polypeptide-related sequence B | |
| AVL9 | 1.8742172 | Down | 2.70E-06 | AVL9 homolog (S. cerevisiase) | |
| PTGS2 | 1.8690909 | Down | 6.22E-05 | Prostaglandin-endoperoxide synthase 2 | |
| GRINA | 1.8647411 | Down | 0.0017328 | Glutamate receptor, ionotropic | |
| BTN3A2/BTN3A3 | 1.857413 | Down | 1.95E-04 | Butyrophilin, subfamily 3, member A2//A3 | |
| FURIN | 1.8437475 | Down | 9.03E-04 | Furin (paired basic amino acid cleaving enzyme) | |
| STC1 | 1.8405004 | Down | 2.87E-05 | Stanniocalcin 1 | |
| RAP2C | 1.839736 | Down | 4.87E-04 | RAP2C, member of RAS oncogene family | |
| ADAM12 | 1.8122648 | Down | 6.18E-04 | ADAM metallopeptidase domain 12 | |
| GREM1 | 1.8109983 | Down | 5.69E-04 | Gremlin 1, cysteine knot superfamily, homolog | |
| GREM1 | 1.8081648 | Down | 1.07E-04 | M | Gremlin 1, cysteine knot superfamily, homolog |
M, T, P means Microcosm, TargetScan, and PicTar-Vert miRNA target prediction databases.