Table 2.

Number of patients with at least one exacerbation by discontinuation of anticholinergics

	Placebo (n = 5868) n (%)	Tiotropium (n = 6295) n (%)	Odds ratio (95% confidence interval)	P value
Discontinued	1187 (42.7)	1221 (39.9)	0.88 (0.80–0.93)	0.0223
Not discontinued	1294 (41.9)	1154 (35.7)	0.77 (0.69–0.85)	<0.0001
Difference				0.0620

Notes: Results are based on a logistic regression model with terms for treatment, subgroup, trial and treatment *subgroup interaction. The denominator for the percentages is the number of patients in each combination of subgroup and treatment: discontinued, n (placebo) = 2783, n (tiotropium) = 3063; not discontinued n (placebo) = 3085, n (tiotropium) = 3232.