Fig. 7.
The PLC inhibitor, U73122, does not prevent m-3M3FBS-induced inhibition of IL. (A) Peak IL by U73122 (1μM) and both U73122 (1μM) and m-3M3FBS (10μM) was plotted as a function of time. (B) Representative traces where ramp depolarizations were applied from −80mV to +80mV over 500ms every 1 minute in (a) control, (b) in the presence of U73122 and (c) in the presence of U73122 and m-3M3FBS. (C) Summary of peak IL at 0 mV by U73122 (1μM) and both U73122 (1μM) and m-3M3FBS (10μM) (n=7). * and ** denote P<0.05 and P<0.001, respectively.