Table 1.
Physicochemical characteristics of the nanoparticles and microspheres
| Formulation | Particle size | Loading (%) | EE (%) | PVA content | (%) Zeta potential (mV) | PDI |
|---|---|---|---|---|---|---|
| PEG-PLGA nanoparticles (nm) | 147.32 ± 31.93 | 8.03 ± 1.21 | 75.97 ± 8.67 | 0.6 ± 1.1 | −16.2 ± 0.3 | 0.39 ± 0.15 |
| PLGA nanoparticles (nm) | 127.31 ± 26.18 | 3.27 ± 1.36* | 65.45 ± 9.62* | 6.3 ± 2.5* | −33.3 ± 0.2 | 0.31 ± 0.18 |
| PEG-PLGA microspheres (μm) | 45.79 ± 6.87* | 15.32 ± 1.21* | 91.84 ± 3.29* | 0.3 ± 0.6 | −25.1 ± 0.5 | 0.46 ± 0.19 |
| PLGA microspheres (μm) | 27.45 ± 4.26* | 9.21 ± 1.73 | 82.74 ± 5.67 | 3.2 ± 1.9* | −57.9 ± 0.6 | 0.73 ± 0.22 |
Note:
*
Significantly different from PEG-PLGA nanoparticles (P < 0.05).
Abbreviations: EE, entrapment efficiency; PLGA, poly(DL-lactide-co-glycolide); PEG-PLGA, poly(ethylene glycol) modified poly(DL-lactide- co-glycolide); PVA, polyvinyl alcohol; PDI, polydispersity index.