Figure 3. Comparative arterial blood carbon dioxide partial pressure (PaCO2, plots) and arterial pH (bars) in groups exposed to high stretch ventilation.
HV25-sham: animals exposed to 25 cmH2O Paw only. HV25-stim: animals exposed to 25 cmH2O Paw and receiving vagal stimulation. HV25-stim/MLA, vagal stimulation was associated to a pre-treatment with a specific antagonist of the alpha7 nicotinic acetylcholine receptor, methyllycaconitine (MLA). HV25-PNU: animals exposed to 25 cmH2O Paw and pre-treated with the alpha7 nicotinic acetylcholine receptor agonist PNU. Symbol $ indicates significant differences versus baseline in a same group. Symbol * indicates significant differences versus HV25-sham group at the same time.