Figure 7. Lung histopathology of animals exposed to high stretch ventilation.

Hematoxylin-eosin-saffron stained sections. Original magnification of pictures x50; original magnification of insets x100. The intra-alveolar inflammation with alveolar macrophages can be seen in the HV₂₅-sham slide and, at a lesser level, in the HV₂₅-stim slide. Note the alveolar polymorphonuclear leukocytes in addition to the macrophages in HV₂₅-stim/MLA group. By contrast, no intra-alveolar inflammatory cell accumulation was seen in the HV₂₅-PNU group. In every group, the inter-alveolar walls were moderately edematous and inflamed with inflammatory mononuclear cells. The alveolar edema is here especially marked on the HV₂₅-sham slide.