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. 2011 Aug 8;6(8):e22386. doi: 10.1371/journal.pone.0022386

Figure 8. Concentrations of lung and plasma IL-6 and lung substance P contents after high pressure ventilation.

Figure 8

IL-6 in lung extracts (top panel) and in plasma (middle panel), measured by ELISA. SP lung contents assessed by HPLC (bottom panel). Individual (circles) and median (horizontal bars) values are indicated for IL-6. SP is presented as mean values (solid bars) and standard error. HV25-sham: injurious ventilation. HV25-stim: injurious ventilation associated with vagal stimulation. HV25-stim/MLA: injurious ventilation associated with vagal stimulation and pre-treatment with the alpha7 nicotinic acetylcholine receptor blocking agent MLA. HV25-PNU: injurious ventilation associated with pre-treatment with the alpha7 nicotinic acetylcholine receptors agonist PNU. Asterisks indicate significant differences versus HV25-sham group (*p<0.05, ** p<0.01; *** p<0.001).