Table 2. Age-induced changes.

GO term	Gene count	P value	FDR
Chromatin remodeling
GO:0051276∼chromosome organization	43	0.0001	0.25
GO:0006325∼chromatin organization	35	0.0003	0.52
GO:0006333∼chromatin assembly or disassembly	17	0.0003	0.59
GO:0006323∼DNA packaging	17	0.0001	0.20
GO:0031497∼chromatin assembly	14	0.0002	0.30
GO:0043933∼macromolecular complex subunit organization	40	0.0001	0.20
GO:0065003∼macromolecular complex assembly	35	0.0008	1.38
GO:0034621∼cellular macromolecular complex subunit organization	30	0.0001	0.18
GO:0034622∼cellular macromolecular complex assembly	26	0.0004	0.72
GO:0065004∼protein-DNA complex assembly	14	0.0002	0.35
GO:0034728∼nucleosome organization	14	0.0002	0.35
GO:0006334∼nucleosome assembly	13	0.0005	0.86
Antigen presentation
GO:0019882∼antigen processing and presentation	13	0.0009	1.67
GO:0048002∼antigen processing & presentation of peptide antigen	10	0.0001	0.20
GO:0002474∼antigen processing & presentation via MHC I	7	0.0002	0.35
Cell cycle
GO:0000278∼mitotic cell cycle	28	0.0011	2.00
GO:0022403∼cell cycle phase	36	0.0004	0.68
GO:0007049∼cell cycle	57	0.0004	0.72
GO:0022402∼cell cycle process	39	0.0015	2.67
Hormone response
GO:0009725∼response to hormone stimulus	21	0.0009	1.50
GO:0009719∼response to endogenous stimulus	23	0.0006	1.11
GO:0043434∼response to peptide hormone stimulus	15	0.0008	1.33
Synapse organization
GO:0050808∼synapse organization	10	0.0017	3.03
GO:0050803∼regulation of synapse structure and activity	6	0.0013	2.26
Lipid metabolism
GO:0045834∼positive regulation of lipid metabolic process	7	0.0022	3.87

Enriched functional categories associated with aging. GO terms are ordered within subcategories by Fisher exact test p value (i.e., EASE score) with highest enriched term at the top of each list. False discovery rates (FDR) are expressed as percentage scores.