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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Hear Res. 2011 May 1;278(1-2):77–85. doi: 10.1016/j.heares.2011.04.011

Figure 6. Inhibition of SGN neurite growth by JNK inhibitor is reversible.

Figure 6

Cultures were fixed 12, 36 or 60 hours after plating. Control cultures were maintained in 25K/0.1% DMSO. SP600125-treated cultures had SP600125 present from 12 to 36 h after plating. Shown are means ± SEM (n = 5 replicate cultures) with the mean neurite length printed in each bar. The approximate mean rate of neurite growth is shown in gray for each 24 h interval, 12–36 h and 36–60 h post-plating. This was determined by dividing the difference in mean neurite length by 24 h. SP600125 reduces the neurite growth rate when present in the 12–36 h interval but growth returns to a nearly control rate in the 36–60 h during which SP600125-treated SGNs had 24 h to extend neurites after SP600125 withdrawal.