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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Mol Cell Neurosci. 2011 May 9;48(1):1–8. doi: 10.1016/j.mcn.2011.05.002

Figure 4.

Figure 4

nmnat is required for the maintenance of motor neuron dendrites and axons. (A) Dendritic morphology of a wild-type intersegmental nerve b (ISNb) motor neuron. (B) Dendrites of ISNb nmnatΔ4792 MARCM clones exhibit a significant reduction in dendritic branching. Dotted circles indicate dendrites. (C,D) Quantification of terminal dendritic branching (mean ± SD) (C) and total dendritic field area (mean ± SD) (D) for wild-type (n = 14) and nmnatΔ4792 (n = 20) ISNb motor neuron clones. Double asterisk denotes p < 0.001 (Student’s t-test). (E) Axonal and dendritic projections of wild-type motor neuron clones at 120 hrs AEL. (F) Axons and dendrites of nmnatΔ4792 motor neuron clones are largely intact at 72 hrs AEL. (G) nmnatΔ4792 motor neuron clones exhibit severe beading and fragmentation of axons and loss of dendrites by 120 hrs AEL. Arrows indicate cell body, arrowheads indicate axons. Anterior is up. Scale bar represents 25 µm (A,B) and 50 µm (E–G).