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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Peptides. 2011 Jun 28;32(8):1685–1699. doi: 10.1016/j.peptides.2011.06.017

Figure 2.

Figure 2

Comparison of affinities for binding and potencies for activation of various natural Bn related peptide agonists for human NMB receptors overexpressed in low density on NCI-H1299 lung cancer cells [left panels] or in Balb 3T3 cells transfected with hNMBR [right panels] The upper panels [Panels A and B] show the affinities from binding studies using 50 pM 125I-[D-Tyr0]NMB as the ligand. The lower panels [panels C and D] show their potencies for activating phospholipase C and stimulating changes in total cellular [3H]inositol phosphates ([3H]IP). The experimental conditions were as outlined in the legend to Table 2 and as described under Materials and Methods. Values are mean ± S.E.M. from at least four experiments. Full names of peptide abbreviations are shown in Table 1.