Table 2.

Cognitive decline as a function of occupational position, estimates derived from linear mixed models using 3 assessments over 10 years.

	OCCUPATION POSITION
	High (N=3140) 14% women	Intermediate (N=3289) 31% women	Low (N=1025) 73% women
Cognitive tests†	10-year decline (95% CI)	10-year decline (95% CI)	10-year decline (95% CI)	≠P for interaction
Reasoning (AH4-I)	−3.47 (−3.69, −3.26)	−3.43 (−3.64, −3.21)	−4.04 (−4.47, −3.60)*	0.04
Memory (20-word list)	−0.77 (−0.87, −0.68)	−0.61 (−0.70, −0.51)*	−0.46 (−0.64, −0.28)**	0.003
Phonemic fluency (“s” words)	−1.72 (−1.85, −1.59)	−1.48 (−1.61, −1.35)*	−1.54 (−1.79, −1.29)	0.04
Semantic fluency (animal names)	−1.53 (−1.65, −1.41)	−1.26 (−1.38, −1.14)**	−0.89 (−1.12, −0.65)***	<0.001
Vocabulary (Mill-Hill)	0.11 (0.03, 0.19)	0.08 (0.00, 0.16)	0.06 (−0.10, 0.22)	0.83
Global cognitive score±	−0.27 (−0.28, −0.26)	−0.23 (−0.25, −0.22)***	−0.21 (−0.24, −0.19)***	0.001

^†Range of cognitive tests: Memory (0–20), Reasoning (0–65), Phonemic and Semantic Fluency (0.35) and Vocabulary (0–33).

^≠The interaction term assesses whether the decline was different in the three occupational groups. Further tests compared the high reserve group to the other two groups and here

^*p<0.05,

^**p<0.01,

^***p<0.001.

^±Score calculated by converting raw scores on each test to z-scores using the baseline mean and standard deviation and then averaged across the five tests.