Table 1.
Treatment Arms | Study Reference | Dosage and Treatment Times |
---|---|---|
Arm 1 (CP) | Ozols et al, 2003 [4] | 135 mg/m2 P over 3 hrs + C (AUC 7.5) 21-day cycle × 6 |
Arm 2 (CP+P) | Markman et al, 2003 [5] | CP as above followed by *175mg/m2 IV P over 3 hrs 28-day cycles × 12 |
Arm 3 (CPB+B) | Markman et al, 2003 [5] | 175 mg/m2 P + C (AUC 6) × 1 cycle 175 mg/m2 P + C (AUC 6) + B 15 mg/kg × 5 cycles B 15 mg/kg × 16 cycles |
Note. CP – carboplatin and paclitaxel; CP+P, carboplatin, paclitaxel and paclitaxel maintenance; CPB+B, carboplatin, paclitaxel, bevacizumab, and bevacizumab maintenance; AUC, area under curve