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. Author manuscript; available in PMC: 2012 Aug 1.

Published in final edited form as: Peptides. 2011 May 27;32(8):1575–1580. doi: 10.1016/j.peptides.2011.04.029

Table 1.

Effects of ovariectomy and increased hypothalamic rAAV-lep gene expression on cancellous bone mass and architecture in the 2nd lumbar vertebra.

Endpoint	Treatment				ANOVA P<
Endpoint	Intact control	Ovx + pair-fed	Ovx + rAAV-GFP	Ovx + rAAV-Lep	ANOVA P<
Bone volume/tissue volume (%)	38.6 ± 1.0	29.2 ± 2.4^a	26.4 ± 1.0^a	23.3 ± 1.3^a	0.001
Trabecular number (mm⁻¹)	4.5 ± 0.0	3.7 ± 0.2^a	3.6 ± 0.1^a	3.2 ± 0.1^a	0.001
Trabecular thickness (μm)	82 ± 2	79 ± 2	74 ± 1^a	74 ± 1^a	0.003
Trabecular separation (μm)	203 ± 1	262 ± 16^*	264 ± 8^a	304 ± 15^a	0.001

Mean ± SE.

^a

Different from intact control, P < 0.05.

^*

P < 0.1.