Table 2.
Effects of ovariectomy and increased hypothalamic rAAV-lep gene expression on cancellous bone mass and architecture in the proximal tibial metaphysis.
| Endpoint | Treatment
|
ANOVA P< | |||
|---|---|---|---|---|---|
| Intact control | Ovx + pair-fed | Ovx + rAAV-GFP | Ovx + rAAV-Lep | ||
| Bone area/tissue area (%) | 30.4 ± 3.3 | 12.4 ± 2.7a | 12.5 ± 1.7a | 9.5 ± 0.9a | 0.001 |
| Trabecular number (mm−1) | 5.1 ± 0.4 | 2.5 ± 0.3a | 2.4 ± 0.3a | 1.9 ± 0.2a | 0.001 |
| Trabecular thickness (μm) | 60 ± 3 | 49 ± 6 | 52 ± 2 | 50 ± 2 | 0.171 |
| Trabecular separation (μm) | 143 ± 15 | 390 ± 59a | 398 ± 52a | 508 ± 59a | 0.001 |
Mean ± SE.
a
Different from intact control, P < 0.05.