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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Hear Res. 2011 May 26;278(1-2):106–112. doi: 10.1016/j.heares.2011.05.010

Fig. 3.

Fig. 3

Mean (−SD) ABR thresholds showing delay of age-related hearing loss by anti-epileptic drugs. (A) Thresholds for controls (n=5, three males and two females) and mice administered trimethadione in drinking water for one week (n=6, three of each sex; all 8-month-old B6 WT mice; two-way ANOVA, F = 2.012, p = 0.162). (B) Threshold shifts occurring between 10-12 months of age for female B6 controls and mice treated with trimethadione for two months (n=5 per group, started at 10 months; two-way ANOVA, F = 89.868, p < 0.001). (C) ABR threshold shifts occurring between 10-12 months of age for female B6 controls and mice treated with ethosuximide for two months (n=3 per group, started at 10 months; 3Ctwo-way ANOVA, F = 15.906, p < 0.001).