Table 3.
Pharmacokinetic parameters of pentoxifylline and its metabolite
| PTX (N = 10) |
PTX metabolite (N = 9) |
|
|---|---|---|
| Cmax (ng/mL) | 151 (82 - 332) | 94 (35 - 291) |
| Tmax (hours) | 10 (2 - 24) | 12 (4 - 24) |
| AUC0-24 (ng . h/L) * | 2828 (1743 - 3052) | 1567 (831 - 1585) |
| AUC0-∞ (ng . h/L) * | 7641 (5123 - 9177) | 2314 (852 - 2855) |
* Data restricted to seven subjects with sufficient data points
Data are median (range)
Cmax : maximum concentration; Tmax : time to maximum concentration;
AUC0-24 : area under the curve (0 to 24 hours); AUC0-∞ : area under the curve (0 to infinity)