EPFRs decrease baseline diastolic left ventricular function in closed chest rats. Rats were treated with DCB230 (8 mg/kg, i.t.) or vehicle 24 hrs prior to the experiment. Left ventricular function was measured using Millar pressure-volume catheters. Data are mean ± SEM. Abbreviations: EDV, end diastolic volume; EDP, end diastolic pressure; −dP/dtmin, diastolic decrease in pressure vs time; Tau (G). ***p<0.001, **p<0.01, and * p<0.05.