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. 2010 Dec 6;1:139. doi: 10.3389/fphar.2010.00139

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Copyright © 2010 Muntean, Horvat, Behler, AbouAlaiwi, Nauli, Williams and Nauli.

This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.

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Verapamil causes a physiological reflex that induces calcium sensitivity in anesthetized zebrafish heart. Calcium sensitivity is defined as the contractile force produced by a given increase in cytosolic calcium. When the values of contractile forces were divided by the changes in cytosolic calcium, the myogenic calcium sensitivity increased significantly only in anesthetized fish treated with verapamil. This indicates that verapamil as a calcium channel blocker has a greater complexity in the myogenic heart contractility in response to anesthetic. Asterisk denotes a significant difference compared to control.