Table 2.
Mechanism of resistance of tet and otr genes.
| Efflux (27) | Ribosomal protection (12) | Enzymatic (3)c | Unknowna |
|---|---|---|---|
| tet(A), tet(B), tet(C), | tet(M), tet(O), tet(S), | tet(X) | tet(U) |
| tet(D), tet(E) | tet(W), tet(32), | ||
| tet(G), tet(H), tet(J), | tet(Q), tet (T), tet(36) | tet(34) | |
| tet(V), tet(Y) | |||
| tet(Z), tet(30), | otr(A), tetB(P)b, | tet(37) | |
| tet(31), tet(33) | tet(44), tet | ||
| tet(35)d | |||
| tet(39), tet(41) | |||
| tet(K), tet(L), tet(38) | |||
| tetA(P), tet(40), | |||
| tet(42), tet(43) | |||
| otr(B), otr(C), tcr3 |
atet (U) has been sequenced but does not appear to be related to either efflux or ribosomal protection proteins; btetB(P) is not found alone and tetA(P) and tetB(P) are counted as one operon; ctet(X) and tet(37) are unrelated but both are NADP-requiring oxidoreductases: tet(34) similar to the xanthine–guanine phosphoribosyl transferase genes of V. cholerae;dNot related to other tet efflux genes; tet(37), tet(43).