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Salmonella Typhimurium exploits a sentinel function of enterocytes. Upon invasion, S. Typhimurium escapes into the cytosol in a fraction of epithelial cells, thereby triggering proinflammatory cell death (pyroptosis). Extrusion of pyroptotic epithelial cells into the lumen releases S. Typhimurium primed for epithelial invasion. For further explanation see text.
