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. 2011 Apr 25;2:85. doi: 10.3389/fmicb.2011.00085

Figure 2.

Figure 2

NLRC4 detection of S. typhimurium. There are two major phases of S. typhimurium growth, extracellular in the gut lumen (modeled on the left), and intracellular within macrophages and epithelial cells (modeled on the right). While SPI1 and flagella are expressed in the gut lumen, SPI2 is expressed in the intracellular compartment. Inadvertent translocation of flagellin (blue) or the SPI1 T3SS rod protein, PrgJ (red), is detected by NLRC4, while the SPI2 rod, SsaI (green), is not detected. NLRC4 can detect intracellular adapted S. typhimurium via flagellin transfer through the SPI2 T3SS, albeit much less efficiently than gut adapted bacteria. EC: eukaryotic cytosol. PM: eukaryotic cell plasma membrane. EX: extracellular space. OM: bacterial outer membrane. IM: bacterial inner membranel. BC: bacterial cytosol.