Figure 2. Patients with a Sustained Virologic Response, According to Treatment Group and Analysis.

The percentages of patients with a sustained virologic response are shown. The prespecified primary analysis involved all patients who were randomly assigned to a treatment group and received at least one dose of any study medication. The prespecified secondary analysis involved all patients who were randomly assigned to a treatment group and received at least one dose of boceprevir or placebo. Prior relapse was defined as an undetectable HCV RNA level at the end of prior therapy without subsequent attainment of a sustained virologic response. Prior nonresponse was defined as a decrease in the HCV RNA level of at least 2 log₁₀ IU per milliliter by week 12 of prior therapy but a detectable HCV RNA level throughout the course of prior therapy, without subsequent attainment of a sustained virologic response. Poor response to interferon was defined as a decrease in the HCV RNA level of less than 1 log₁₀ IU per milliliter after the 4-week lead-in period (treatment week 4). Good response to interferon was defined as a decrease in HCV RNA level of 1 log₁₀ IU per milliliter or more after the lead-in period. For the primary analysis, the absolute difference between group 2 and group 1 was 37.4 percentage points (95% confidence interval [CI], 25.7 to 49.1; P<0,001), and between group 3 and group 1, 45.2 percentage points (95% CI, 33.7 to 56.8; P<0.001). For the secondary analysis, the absolute difference between group 2 and group 1 was 39.1 percentage points (95% CI, 27.2 to 51.0; P<0.001), and between group 3 and group 1, 45.1 percentage points (95% CI, 33.4 to 56.8; P<0.001). The P values were calculated with the use of the Cochran-Mantel-Haenszel chi-square test after adjustment for baseline stratification factors. I bars are 95% confidence intervals.