Fig. 3.

Elevated serum IGF-1 levels are sufficient to preserve cancellous bone in the absence of tissue IGF-1 action. Cancellous bone morphology was analyzed at the distal femur by µCT. Bone volume fraction (BV/TV) (A), trabecular thickness (Tb.Th) (B), tissue mineral density (TMD) (C), trabecular number (Tb.N) (D), and trabecular spacing (Tb.Sp) (E) were measured at 4, 8, and 16 weeks of age. Data are presented as mean ± SEM of n = 10 to 15 mice in each group at each time point. *p < .05 comparing KO-HIT mice with control. ^#p < .05 comparing HIT mice with control.