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. 2010 Jan 14;25(6):1257–1266. doi: 10.1002/jbmr.20

Fig. 4.

Fig. 4

Elevated serum IGF-1 levels restore bone mechanical properties in the absence of tissue IGF-1 action. Mechanical properties were assessed in femurs by four-point bending. Stiffness (A), which indicates resistance to bending, and maximal load (B), which indicates stress at fracture, were measured at 8 and 16 weeks of age. Data are presented as mean ± SEM of n = 10 to 15 mice in each group at each time point. Transversal growth rate indicated by increases in Tt.Ar (C) and Ct.Ar (D) and morphology have been analyzed over two growth periods: from 4 to 8 weeks and from 8 to 16 weeks of age using the following formula: Growth rate of Ct.Ar between 4 and 8 weeks = (CtAr8w – CtAr4w)/CtAr4w. Data are presented as mean ± SEM of n = 10 to 15 mice in each group over each period of time. Serum osteocalcin levels (E) were measured at 8 weeks of age. *p < .05 comparing KO-HIT mice with control. #p < .05 comparing HIT mice with control.